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Extensively drug-resistant gonorrhoea: risk of further dissemination within and across Europe

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The study by Eyre et al. in the Eurosurveillance edition of 7 March 2019 reported on two cases of ceftriaxone-resistant Neisseria gonorrhoeae with intermediate resistance to azithromycin diagnosed in England. The two female patients presented in October and November 2018 and developed symptoms following unprotected sex with UK residents, the first during holiday in Ibiza and the second with a man who had been in Ibiza with links to the same sexual network as the first case.

Cultures from both cases yielded N. gonorrhoeae resistant to ceftriaxone, cefixime, tetracycline, penicillin and ciprofloxacin and with intermediate resistance to azithromycin. The isolates were sensitive to spectinomycin and had low MIC values for gentamicin and ertapenem suggesting susceptibility to these agents, although breakpoints are not defined. The first case was treated successfully with intramuscular ceftriaxone and oral azithromycin according to UK national treatment guidance at the time.

The second case failed treatment with ceftriaxone intramuscularly and later with intramuscular gentamicin and oral azithromycin, but eventually cleared infection following treatment with ertapenem intravenously 1 g once daily for three days. The second case also had unprotected oral and protected vaginal sex with a male partner when her symptoms initially improved following treatment with ceftriaxone and her partner tested positive with nucleic acid amplification test at the pharynx (pharyngeal culture and urine NAAT were negative). Since it was considered likely that he was infected by the second case, the partner was successfully treated with ertapenem intravenously.

The isolates were sequenced and shown to be indistinguishable and comparisons with previously reported ceftriaxone-resistant isolates indicated that they were part of the FC428 clone that likely originated in Southeast Asia or China before spreading to multiple countries.

ECDC comment

Infections with multidrug- and extensively drug-resistant N. gonorrhoeae that are part of the FC428 or other clones have been reported from several countries worldwide in the last two years. In 2018, ECDC published a rapid risk assessment on three cases that were diagnosed in Australia and England, two of whom had links to Southeast Asia. Additionally, cases have been reported in Canada, Denmark, France and Ireland. Some of these cases reported sexual intercourse with new partners while travelling in Asian countries. However, for the case reported in France and the two recent infections in the UK, it is likely that transmission happened in Europe.

This development is of concern as it is likely that the detected cases represent only a small proportion of the real burden caused by these multidrug-resistant clones. A large proportion of gonorrhoea cases are asymptomatic and additionally, some could be cleared spontaneously. In these situations, opportunities for detecting these strains and stopping transmission will be missed. Although both the cases in the current report were UK residents, the links to Ibiza, a popular destination for young Europeans, suggest that there is a risk of further dissemination of this strain within and across Europe.

These reports highlight the importance of EU/EEA Member States adopting the measures included as options for response in the ECDC rapid risk assessment and response plan to control multidrug-resistant N. gonorrhoeae that include:

  • strengthening surveillance for antimicrobial-resistant gonorrhoea
  • implementation of treatment failure monitoring; and
  • ensuring that gonorrhoea infections are managed appropriately according to national or European treatment guidelines, including the implementation of test of cure for all cases and effective partner notification.

Sexual health clinicians also need to be informed by public health institutes of this threat in order to be aware of possible cases.

However, effective response to the threat of drug-resistant gonorrhoea depends on a global approach. Strengthened surveillance and case management in regions where these strains are likely to have originated from is crucial in order to limit further spread.

Although both recently reported cases in the UK were successfully treated with ertapenem, use of the drug is not ideal. As mentioned by the authors, this approach may lead to the development of carbapenem resistance in other organisms where carbapenems are used for the treatment of multidrug-resistant infections.

In addition, sexual health clinics are not generally set up for gonorrhoea treatment with intravenous antibiotics for multiple days. New treatment options are urgently needed that are effective at all relevant anatomical sites.

Source: https://www.ecdc.europa.eu/en/news-events/extensively-drug-resistant-gonorrhoea-risk-further-dissemination-within-and-across

Blockchain

BTG Pactual becomes first bank in Brazil to participate directly in the crypto market

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Financial institutions have been increasingly keen on being part of the booming $2 trillion cryptocurrency market, with over 13 of the world’s largest banks pushing roughly $3 billion in funding so far, into cryptocurrency. The latest major news came from Brazil.

One of the leading Brazilian investment banks BTG Pactual has been trending within the crypto community. It launched a new platform enabling customers to make direct investments in cryptocurrencies. Ergo, making it the first major financial institution in Brazil to participate directly in the crypto market.

According to local news outlet, The Rio Times,

“…the launch of Mynt, a platform that allows BTG Pactual Digital and BTG+ clients to trade directly, cryptocurrencies such as bitcoin and ether.”

Andre Porthilo, BTG Pactual’s head of digital assets, stated,

“At this first moment, we will have the two main assets of the market, but we will include other cryptos for trading over time. We will have a complete platform with blockchain-based assets.”

One thing that remained in common with different banks incorporating these tokens is the fact that they have been responding to “demand from our customers who wish to trade crypto.” This news is no different.

Plans

BTG Pactual CEO, Roberto Sallouti laid out his plan of action with this development. He opined, “As a new asset class, we will also have content to educate and inform our customers about these assets and the technology.”

Needless to say, Brazil has witnessed an immense amount of crypto traction. That said, regulators too have taken steps to curb illicit activities. As asserted by the CEO, the said bank will be regulated by both the Brazilian Securities Commission and the local central bank. Moreover,

“With the support of BTG Pactual, Mynt has fundamental differentials in security and credibility…”

Past

The said bank had previously incorporated digital assets in previous operations as well. In 2019, it launched its real estate-backed security token ReitBZ. This step was executed post-examining digital assets for a couple of years. Just recently, the bank announced collaboration with Gemini, the U.S.-based crypto exchange. Gemini provided custody services to the first Bitcoin fund issued by a Brazilian investment bank.

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Source: https://ambcrypto.com/btgpactual-becomes-first-bank-in-brazil-to-participate-directly-in-the-crypto-market

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Basel Committee Crypto Rules Face Backlash

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The information on or accessed through this website is obtained from independent sources we believe to be accurate and reliable, but Decentral Media, Inc. makes no representation or warranty as to the timeliness, completeness, or accuracy of any information on or accessed through this website. Decentral Media, Inc. is not an investment advisor. We do not give personalized investment advice or other financial advice. The information on this website is subject to change without notice. Some or all of the information on this website may become outdated, or it may be or become incomplete or inaccurate. We may, but are not obligated to, update any outdated, incomplete, or inaccurate information.

You should never make an investment decision on an ICO, IEO, or other investment based on the information on this website, and you should never interpret or otherwise rely on any of the information on this website as investment advice. We strongly recommend that you consult a licensed investment advisor or other qualified financial professional if you are seeking investment advice on an ICO, IEO, or other investment. We do not accept compensation in any form for analyzing or reporting on any ICO, IEO, cryptocurrency, currency, tokenized sales, securities, or commodities.

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Source: https://cryptobriefing.com/basel-committee-crypto-rules-face-backlash/?utm_source=main_feed&utm_medium=rss

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Blockchain

Ethereum NFT Game Sorare Fantasy Soccer Raised $680 Million

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Ethereum NFT game Sorare fantasy soccer just raised $680 million and it is now valued at $4.3 billion while launching a US office so let’s read more today in our latest Ethereum news.

The Ethereum NFT game Sorare fantasy soccer raised $680 million and the french startup now plans to expand into other sports as well as to onboard women’s soccer teams and US office. Sorare is an Ethereum-based fantasy soccer game based on NFT trading cards and grew dramatically in 2021 with a rising base and huge trading volume not to mention the new licensed teams in the mix. Today, however, the startup is using the momentum with the announcement of a new funding round.

NFT Game Founder, scammer, eth, cryptopunks

The $680 million Series B round values the company at $4.3 billion after a $50 million Series A round which was announced back in February and the new series was led by Japanese tech and investment conglomerate SoftBank that has a number of crypto industry dealings through SBI holdings financial services division. Sorare is focused on soccer with players from more than 175 licensed clubs like FC Barcelona, Juventus FC, and Paris Saint Germain FC as some of the most popular. Nicolas Julia, the co-founder and CEO of Sorare said that this week the company plans to expand into other sports and it will open a US-based office in the upcoming months to help “continue to grow with fans and sports leagues.” He continued:

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“We have ambitious plans to keep growing Sorare into a sports entertainment giant. The new funding will be used to help us continue to grow a world-class team, expand to new leagues and new sports, and keep improving our experience for users, including shipping a mobile app.”

nba top shot

Dapper Labs’ NBA Top Shot is similar to Sorare, built around NFTs and based on professional athletes. An NFT acts like a deed of ownership to a scarce digital item so in the case of Sorare, it’s a digital trading card that can be purchased and resold with each available in limited quantity. One NFT card can even reach $290,000. Unlike Top Shot, however, Sorare has an ongoing game component and is similar to other fantasy sports in that you can choose your top players each week as well as the leagues with other users. Sorare also has close ties with Ubisoft as it took the accelerator program this year.

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Source: https://www.dcforecasts.com/ethereum-news/ethereum-nft-game-sorare-fantasy-soccer-raised-680-million/

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